Castor Oil Derivative
OMSOL grades are chemically castor oil derivatives. They are non-ionic solubilizers and emulsifying agents obtained by reacting hydrogenated castor oil with ethylene oxide. They consist t hydrophobic and hydrophilic part. They are almost tasteless and odorless. They are used as solubilizer for fat-soluble vitamins, perfumes, essential oils and other hydrophobic pharmaceuticals. They have ability to solubilize or emulsify oil soluble ingredients and convert them
Into clear transparent solution or stable emulsion respectively. It improves the solubility of poorly soluble drugs (BCS class II and class IV).
OMSOL range improves water solubility of major water insoluble products. It is compatible with most of all ingredients. It helps to solubilize different pharmaceutical active ingredients like Acetaminophen, Bromhexidine HCL, Dextromethorphan HBr, Povidone iodine, Loxapine Succinate, Vitamins like vitamin A palmitate, vitamin D, vitamin E acetate etc. It is also used as solubilizer and stabilizer for oils and perfume in cosmetic industries.
It is generally used between 3.0% to 5.0% w/w of API to improve dissolution of poorly soluble active ingredients like Cefuroxime Axetil, Cefpodoxime proxetil, Albendazole etc. It should be mixed with API with or without heating and then dissolved in vehicle (Aqueous / Non aqueous).
OMSOL: • Modify the polarity of water. • Alter various properties like density, surface tension, viscosity, boiling point and specific heat of solution in various ways. • Wetting the surface of solutes by lowering the contact angle between the solute and the wetting liquid. • Increases the solvation / hydration of solutes. • It solubilize the insoluble particles by converting them into small (Nano) size particles with or without heating
OMSOL range is excellent versatile nonionic Emulsifying agent.lt emulsifies major hydrophobic
Substances like fatty acids, fatty alcohols, mineral oil etc.It is suitable to obtain cream and lotions, also can be used as stabilizer for skin care. It has an excellent emulsify ability, suitable for emulsification of mineral oil, natural oil, stearyl etc. It can obtain a steady system when used alone.
OMSOL range improves moisturizing effect and soft feeling.
OMSOL range solubilizes insoluble oily substances in aqueous system and hence it improves transparency and shining In cosmetic formulation, it impacts elegance appearance of products such as shaving gel, hair styling gel, hand wash gel etc. In pharmaceutical syrup formulations, it improves transparency.
20 Kg , 50 Kg in Plastic Carboys
OMSOL range retards volatilities of solvents. It can be used for highly volatile products like after shaving lotion, perfumes etc. to retain its effect for longer period.
OMSOL grades are essentially non-toxic and non-irritant material.
The solubilizing capacity of the various active ingredients with OMSOL grades is given in different ratio as follow
Active ingredient (1 gm.) | OMSOL S-140 (gm.) | OMSOL S-150 (gm.) | OMSOL S-135 (gm.) |
---|---|---|---|
Acetaminophen | _ | 5 | 5 |
Vitamin A PaImitate | 5 | _ | 5 |
Vitamin D | 5 | _ | 4 |
Vitamin E Acetate | 5 | _ | 4 |
Bromhexine Hydrochloride | _ | 30 | _ |
Ambroxol Hydrochloride | _ | 15 | _ |
Cyproheptadine Hydrochloride | _ | 60 | _ |
Dextromethorphan Hydrobromide | _ | 5 | _ |
Povidone iodine | 0.3 | _ | _ |
Cod liver oil | 10 | _ | _ |
Name | OMSOL S-140 | OMSOL S-150 | OMSOL S-135 |
---|---|---|---|
Saponification value | 45-69 | 45-55 | 60-75 |
Hydroxyl Value | 60-80 | 65-75 | 65-80 |
Congealing Temperature | 16-26°C | 5-15°C | |
pH value of 10 % aqueous solution | 6.0-7.0 | 6.0-7.0 | |
Water Content | NMT 3.0% | NMT 3.0% | NMT 3.0% |
HLB Value | 14-16 | 14-16 | 12-14 |
Characteristics | OMSOL S-140 | OMSOL S-150 | OMSOL S-135 |
---|---|---|---|
Chemical Name | PEG-40 Hydrogenated Castor Oil (USP/NF) | PG, PEG-40 Hydrogenated Castor Oil (In House) | PEG-35 Castor oil (USP/NF) |
Description | White to pale yellow Viscous liquid or soft thin paste | White to pale yellow Viscous liquid | White to pale yellow Viscous liquid |
Odor | Odorless | Odorless | Odorless |
Taste | Taste | Taste | Taste |
Miscibility | At elevated temperatures, it forms clear mixtures with fatty acids and fatty alcohols. | ||
Stability | OMSOL grades are stable and does not turn rancid unless subjected to excessive heat. | ||
Solubility | It forms clear solutions, in water, ethanol, 2 - propanol, n-propanol, ethyl acetate, chloroform, | It forms clear solution in water, ethanol, 2 - propanol, n-propanol, ethyl acetate, chloroform, carbon tetrachloride, | It forms clear solutions in water, ethyl alcohol, n-propyl alcohol, isopropyl alcohol, ethyl acetate, chloroform, carbon |
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